Hero # SNRIs for Depression Serotonin and norepinephrine reuptake inhibitors, or SNRIs, are antidepressants that affect both serotonin and norepinephrine signaling.

Common examples FDA’s consumer guide lists duloxetine, venlafaxine, levomilnacipran, and desvenlafaxine in the SNRI class.

Potential benefits SNRIs may be considered when a clinician wants to target depression symptoms through both serotonin and norepinephrine pathways. Choice depends on symptoms, side-effect profile, history, and coexisting conditions.

Common side effects FDA lists nausea, vomiting, dry mouth, constipation, fatigue, drowsiness, dizziness, sweating, and sexual problems as common SNRI side effects.

Less common but serious risks FDA lists increased blood pressure, abnormal bleeding or bruising, and seizures among less common but serious SNRI risks. Patients should also ask about serotonin syndrome.

Warnings and cautions

SNRIs should not be taken with MAOIs, and FDA advises using care in people with liver or kidney problems and caution in those with narrow-angle glaucoma.

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